Alphy was born as the youngest daughter of Mr. Thomas and Mrs. Molly at Angamaly, Kerala. Her father runs a furniture shop, while mother was a head nurse (retd). at Govt. hospital Angamaly. She has an elder sister, Deepa. She completed M.Tech (CSE) from Sengunthar College of Engineering at Erode, Tamil Nadu. Alphy works as a software engineer at Accenture, Chennai.
Alphy Panjikaran was selected as the photo queen of Vanitha, a popular malayalam magazine. She started her career in acting with the film ‘Sunday Holiday’ directed by Jis Joy. She acted in the role of Asif Ali’s sister in the film. Alphy played the lead lady in ‘Shikkari Shambhu’, a comedy drama thriller film directed by Sugeeth. She played the character role of Revathy, a college student in the film. Alphy has also acted in the film ‘Mayanadhi’.