Kalyani was born as the daughter of Mr. Priyadarshan and Mrs. Lissy. Her father is a filmmaker, while mother an actress. She has a brother named Sidharth. Kalyani studied at Parsons School of Design New York, USA.
Kalyani started her career as an assistant director of Vikarm Kumar for the tamil film ‘Irumugan’. She made her acting debut with the telugu film ‘Hello’ directed by Vikram Kumar.
Kalyani is paired opposite Akhil Akkineni in the film. Touted as a romantic action film, ‘Hello’ is slated for release on 22nd December.